Stroke

46 SNPs linked to Stroke across 21 genes, 12 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 46
Notable: 12Magnitude 2 or higher
Well documented: 27
Genes: 21

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs6025F5Very important
- T;T11.4x higher risk of thrombosisBad
- C;T3.5-4.4x risk of thrombosisBad
- C;Cnormal/common risk of thrombosisGood
rs1799963F2Very important
- A;A6.74x risk of thrombosis; 2-20x risk for cerebral stroke if PFO+Bad
- A;G2.8x risk of thrombosis; higher risk for cerebral stroke if PFO+Bad
- G;Gnormal/common risk of thrombosisGood
rs1333049Very important
- C;C1.9x increased risk for coronary artery diseaseBad
- C;G1.5x increased risk for CADBad
- G;GnormalGood
rs2200733LOC729065Important
- C;C0.86x decreased risk of Atrial FibrillationGood
- C;T1.4x increased risk of Atrial Fibrillation and ischemic stroke.Bad
- T;T1.5x increased risk of Atrial Fibrillation and ischemic stroke.Bad
rs7080536HABP2Important
- A;Asignificant increase (2 - 6x?) in risk possible for carotid stenosis, stroke and venous thromboembolismBad
- A;G~2x higher risk for carotid stenosis, venous thromboembolismBad
- G;Gcommon in clinvarGood
rs9340799ESR1Important
- A;AWomen have lower risk of Endometriosis but normal risk for Endometrial Cancer, and more cognitive impairment with age.Good
- A;GWomen have normal (lower) risk of Endometriosis, 0.75x lower risk of Endometrial Cancer, and normal (higher) risk of cognitive impairment.Good
- G;GWomen have 10x risk of Endometriosis, but half the risk of Endometrial Cancer and 0.76x less cognitive impairment.Bad
rs10033464Important
- G;G0.92x decreased risk of Atrial Fibrillation and cardioembolic stroke.Good
- G;T1.28x increased risk of Atrial Fibrillation and cardioembolic stroke.Bad
- T;T1.4x increased risk of Atrial Fibrillation and cardioembolic strokeBad
rs10757278Worth knowing
- A;A0.78x reduced risk for Coronary Heart Disease. 0.77x reduced risk for Brain Aneurysm and Abdominal Aortic Aneurysm.Good
- A;G1.3x risk for Heart Attack. Normal risk for Abdominal Aortic Aneurysm and Brain Aneurysm.Bad
- G;G1.6x risk for Heart Attack; 1.3x risk for Abdominal Aortic Aneurysm and Brain Aneurysm.Bad
rs5443GNB3Worth knowing
- C;Cnormal, but higher risk for several conditionsGood
- C;Tsome riskBad
- T;Tviagra is more likely to have an effect. increased metabolic disease risk.Bad
rs4961ADD1Worth knowing
- G;GnormalGood
- G;T1.8x increased risk for high blood pressureBad
- T;T1.8x increased risk for high blood pressureBad
rs8050894VKORC1Worth knowing
- C;Cwarfarin sensitivity (~2.5 mg/day)Not rated
- C;Gaverage warfarin response (~5 mg/day)Not rated
- G;Gwarfarin resistance (~6.5 mg/day)Not rated
rs1800795IL6Worth knowing
- C;Cless IL6; certain risks, see detailsBad
- C;Gcomplex; see detailsNot rated
- G;Gmore IL6; certain risks, see detailsBad
rs966221PDE4DMinor
- G;G1.5x increased stroke risk certain populationsBad
- A;G1.5x increased stroke riskBad
- A;AnormalGood
rs2231137ABCG2Minor
- T;TSlightly lower stroke riskGood
- C;TSlightly lower stroke riskGood
- C;CMost common genotype, with slightly higher stroke riskBad
rs17611C5Typical
- C;Ccommon in clinvarGood
rs284875TGFBR3Typical
- G;GNo summary available.Not rated
rs989554ERGTypical
- A;ANo summary available.Not rated
rs1042714ADRB2Typical
- C;CnormalGood
- C;Gcomplex; see details for increased risksNot rated
- G;Gcomplex; see details for increased risksNot rated
rs1401296LOC105373608Typical
- C;TNo summary available.Not rated
rs2069830IL6Typical
- C;Ccommon in complete genomicsGood
rs2230500PRKCHTypical
- A;A1.4x increased risk for strokeNot rated
- A;G1.4x increased risk for strokeNot rated
- G;Gnormal riskGood
rs3783799PRKCHTypical
- T;T1.4x increased risk for strokeNot rated
- C;T1.4x increased risk for strokeNot rated
- C;Cnormal riskGood
rs4769874ALOX5APTypical
- G;GNo summary available.Good
rs9951307AQP4Typical
- A;AnormalNot rated
- A;G0.10 decreased risk for brain edema after a strokeGood
- G;G0.10 decreased risk for brain edema after a strokeNot rated
rs10507391ALOX5APTypical
- A;AnormalNot rated
- A;T1.24x increased stroke risk for malesNot rated
- T;T1.24x increased stroke risk for malesNot rated
rs11833579NINJ2Typical
- A;ANo summary available.Not rated
- A;GNo summary available.Not rated
- G;GnormalGood
rs12425791LOC105369597Typical
- A;Apossibly increased risk of strokeNot rated
- A;Gmixed evidence of increased risk for strokeNot rated
- G;GnormalGood

Genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 19 SNPs

Source and license

Adapted from Stroke on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.