rs11833579

A SNP in the NINJ2 gene on chromosome 12. Its most notable genotype is A;A.

Gene
NINJ2
Location
Chr 12666,033 (GRCh38)
Highest magnitude
0.0Typical
Tested on
AncestryDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedNo summary available.Typical · 0.09% of people
  2. A;GNot ratedNo summary available.Typical · 0.039% of people
  3. G;GGoodnormalTypical · 0.052% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 9% A;G 39% G;G 52%
  • European ancestry (Utah)A;A 6% A;G 35% G;G 59%
  • Han Chinese (Beijing)A;A 13% A;G 42% G;G 46%
  • Japanese (Tokyo)A;A 13% A;G 57% G;G 31%
  • Yoruba (Nigeria)A;A 5% A;G 34% G;G 61%
  • African ancestry (Southwest US)A;A 4% A;G 28% G;G 68%
  • Chinese (Denver)A;A 9% A;G 53% G;G 37%
  • Gujarati IndianA;A 11% A;G 44% G;G 44%
  • Luhya (Kenya)A;A 4% A;G 27% G;G 69%
  • Mexican ancestry (Los Angeles)A;A 21% A;G 45% G;G 34%
  • Maasai (Kenya)A;A 4% A;G 27% G;G 69%
  • TuscanA;A 10% A;G 39% G;G 51%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 170 words

rs11833579 is one of 2 SNPs found near the NINJ2 gene on chromosome 12 associated with increased risk for both total stroke and ischemic stroke, based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is rs12425791. Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. Note: a meta-analysis totaling over 8,000 patients did not replicate any association between either rs12425791 or rs11833579 and ischemic (or incident) stroke.content.nejm.org

A;A

1.6x increased risk for stroke in a first study, failed to replicate.

A;G

1.3x increased risk for stroke in a first study, but failed to replicate

Source and license

Adapted from rs11833579 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.