rs2200733(C;C)

0.86x decreased risk of Atrial Fibrillation

Magnitude
1.9Minor
Repute
Good
Frequency
55%Average of 11 populations
On SNPedia
rs2200733(C;C)
Gene
LOC729065

Frequency

Share of people with C;C in each HapMap population.

  • European ancestry (Utah)79%
  • Maasai (Kenya)76%
  • Gujarati Indian75%
  • Tuscan68%
  • Luhya (Kenya)66%
  • Yoruba (Nigeria)56%
  • Mexican ancestry (Los Angeles)55%
  • African ancestry (Southwest US)51%
  • Japanese (Tokyo)30%
  • Han Chinese (Beijing)27%
  • Chinese (Denver)24%

Other genotypes of rs2200733

  1. C;TMost notableBad1.4x increased risk of Atrial Fibrillation and ischemic stroke.Important · 3.036% of people
  2. T;TBad1.5x increased risk of Atrial Fibrillation and ischemic stroke.Important · 3.09% of people

All about rs2200733

Notes

From SNPedia

This is the normal version which makes the heart form properly and makes people less likely to get Atrial Fibrillation (quivering of the top chambers of the heart caused by chaotic electrical signals) and less likely to have an Ischemic Stroke (blocked blood flow to the brain). But also check the other SNP nearby (rs10033464) which slightly affects Atrial Fibrillation too. 23andMe gave this a 4 star confidence rating as it has been heavily studied. It has been confirmed in Europeans and Asians.

Source and license

Adapted from rs2200733(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.