rs12425791
A SNP in the LOC105369597 gene on chromosome 12. Its most notable genotype is A;A: possibly increased risk of stroke
- Gene
- LOC105369597
- Location
- Chr 12674,318 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 20%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedpossibly increased risk of stroke
- A;GNot ratedmixed evidence of increased risk for stroke
- G;GGoodnormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 5% A;G 31% G;G 64%
- European ancestry (Utah)A;A 3% A;G 30% G;G 67%
- Han Chinese (Beijing)A;A 7% A;G 31% G;G 62%
- Japanese (Tokyo)A;A 9% A;G 48% G;G 43%
- Yoruba (Nigeria)A;A 1% A;G 17% G;G 82%
- African ancestry (Southwest US)A;A 0% A;G 18% G;G 83%
- Chinese (Denver)A;A 5% A;G 39% G;G 57%
- Gujarati IndianA;A 10% A;G 38% G;G 53%
- Luhya (Kenya)A;A <1% A;G 12% G;G 87%
- Mexican ancestry (Los Angeles)A;A 12% A;G 53% G;G 35%
- Maasai (Kenya)A;A 2% A;G 17% G;G 81%
- TuscanA;A 8% A;G 37% G;G 55%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 170 words
rs12425791 is one of 2 SNPs found near the NINJ2 gene on chromosome 12 associated with increased risk for both total stroke and ischemic stroke, based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is rs11833579. Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. Note: a meta-analysis totaling over 8,000 patients did not replicate any association between either rs12425791 or rs11833579 and ischemic (or incident) stroke.content.nejm.org
A;A
1.6x increased risk for stroke in an initial study, but failed to replicate in a followup.
A;G
1.3x increased risk for stroke in an initial study, but failed to replicate in a followup.
Source and license
Adapted from rs12425791 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.