rs966221

A SNP in the PDE4D gene on chromosome 5. Its most notable genotype is G;G: 1.5x increased stroke risk certain populations

Gene
PDE4D
Location
Chr 560,206,693 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.5x increased stroke risk certain populationsMinor · 1.524% of people
  2. A;GBad1.5x increased stroke riskTypical · 0.043% of people
  3. A;AGoodnormalTypical · 0.033% of people

SNPedia records rs966221 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 24% A;G 43% A;A 33%
  • European ancestry (Utah)G;G 29% A;G 57% A;A 14%
  • Han Chinese (Beijing)G;G 4% A;G 34% A;A 62%
  • Japanese (Tokyo)G;G 2% A;G 21% A;A 77%
  • Yoruba (Nigeria)G;G 30% A;G 51% A;A 19%
  • African ancestry (Southwest US)G;G 30% A;G 52% A;A 18%
  • Chinese (Denver)G;G 6% A;G 29% A;A 65%
  • Gujarati IndianG;G 27% A;G 42% A;A 32%
  • Luhya (Kenya)G;G 30% A;G 44% A;A 26%
  • Mexican ancestry (Los Angeles)G;G 44% A;G 42% A;A 14%
  • Maasai (Kenya)G;G 27% A;G 44% A;A 29%
  • TuscanG;G 36% A;G 53% A;A 12%

Conditions, medicines and genes

Other PDE4D SNPs

All PDE4D SNPs

Notes

From SNPedia

Notes

A study of 639 Chinese stroke patients concluded that the rs966221(C) allele is associated with increased risk for atherothrombotic strokes (odds ratio 1.51, CI: 1.09-2.10) in this population.

Source and license

Adapted from rs966221 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.