rs12188950

A SNP in the PDE4D gene on chromosome 5. Its most notable genotype is C;C: common in complete genomics

Gene
PDE4D
Location
Chr 560,487,490 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in complete genomicsTypical · 0.087% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 87%
  • European ancestry (Utah)C;C 71%
  • Han Chinese (Beijing)C;C 100%
  • Japanese (Tokyo)C;C 100%
  • Yoruba (Nigeria)C;C 84%
  • African ancestry (Southwest US)C;C 86%
  • Chinese (Denver)C;C 98%
  • Gujarati IndianC;C 90%
  • Luhya (Kenya)C;C 82%
  • Mexican ancestry (Los Angeles)C;C 90%
  • Maasai (Kenya)C;C 92%
  • TuscanC;C 63%

Other PDE4D SNPs

All PDE4D SNPs

Notes

From SNPedia

Notes

In both a multi-site study including 2,500+ Swedish patients and a meta-analysis of 10,000+ patients in 17 publications, no association between rs12188950 and risk for ischemic stroke was found.

Source and license

Adapted from rs12188950 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.