rs10507391

A SNP in the ALOX5AP gene on chromosome 13. Its most notable genotype is A;A: normal

Gene
ALOX5AP
Location
Chr 1330,737,959 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.036% of people
  2. A;TNot rated1.24x increased stroke risk for malesTypical · 0.040% of people
  3. T;TNot rated1.24x increased stroke risk for malesTypical · 0.024% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 36% A;T 40% T;T 24%
  • European ancestry (Utah)A;A 12% A;T 43% T;T 45%
  • Han Chinese (Beijing)A;A 15% A;T 52% T;T 34%
  • Japanese (Tokyo)A;A 11% A;T 38% T;T 51%
  • Yoruba (Nigeria)A;A 84% A;T 14% T;T 2%
  • African ancestry (Southwest US)A;A 61% A;T 35% T;T 4%
  • Chinese (Denver)A;A 13% A;T 47% T;T 40%
  • Gujarati IndianA;A 14% A;T 53% T;T 34%
  • Luhya (Kenya)A;A 80% A;T 19% T;T <1%
  • Mexican ancestry (Los Angeles)A;A 24% A;T 60% T;T 16%
  • Maasai (Kenya)A;A 68% A;T 28% T;T 4%
  • TuscanA;A 14% A;T 56% T;T 30%

Conditions, medicines and genes

Other ALOX5AP SNPs

All ALOX5AP SNPs

Notes

From SNPedia

Show notes, about 160 words

rs10507391, also known as SG13S114, is an ALOX5AP gene SNP that has been defined as part of a haplotype potentially associated with risk for myocardial infarction or ischemic stroke. Details of this haplotype and several related studies are on the ALOX5AP page. One study that specifically found association for rs10507391 involved 639 German ischemic stroke patients. The association was statistically significant (only) in males, with an odds ratio of 1.24 (CI: 1.04-1.55, p=0.017). Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis. Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study. ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos.

Source and license

Adapted from rs10507391 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.