rs4076128

A SNP in the ALOX5AP gene on chromosome 13. Its most notable genotype is A;A: 1.8x increased breast cancer risk for women having high linoleic acid diets

Gene
ALOX5AP
Location
Chr 1330,731,006 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
42%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated1.8x increased breast cancer risk for women having high linoleic acid dietsTypical · 0.038% of people
  2. A;GNot ratednormalTypical · 0.034% of people
  3. G;GNot ratednormalTypical · 0.028% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 38% A;G 34% G;G 28%
  • European ancestry (Utah)A;A 57% A;G 34% G;G 9%
  • Han Chinese (Beijing)A;A 40% A;G 42% G;G 18%
  • Japanese (Tokyo)A;A 55% A;G 39% G;G 7%
  • Yoruba (Nigeria)A;A 0% A;G 22% G;G 78%

Conditions, medicines and genes

Other ALOX5AP SNPs

All ALOX5AP SNPs

Notes

From SNPedia

Notes

Based on a mixed-ethnicity study, women consuming a diet high in linoleic acid (top quartile of intake, >17.4 g/d) and carrying the rs4076128(A;A) genotype were associated with higher breast cancer risk (age- and race-adjusted odds ratio, 1.8, CI: 1.2-2.9) compared with (A;G) and (G;G) genotypes. Among women consuming </=17.4 g/d of linoleic acid, there was no association with breast cancer risk.

Source and license

Adapted from rs4076128 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.