rs10033464

A SNP on chromosome 4. Its most notable genotype is G;T: 1.28x increased risk of Atrial Fibrillation and cardioembolic stroke.

Gene
None listed
Location
Chr 4110,799,605 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGood0.92x decreased risk of Atrial Fibrillation and cardioembolic stroke.Minor · 1.969% of people
  2. G;TMost notableBad1.28x increased risk of Atrial Fibrillation and cardioembolic stroke.Important · 3.028% of people
  3. T;TBad1.4x increased risk of Atrial Fibrillation and cardioembolic strokeImportant · 3.03% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 69% G;T 28% T;T 3%
  • European ancestry (Utah)G;G 82% G;T 16% T;T 2%
  • Han Chinese (Beijing)G;G 62% G;T 33% T;T 5%
  • Japanese (Tokyo)G;G 51% G;T 42% T;T 7%
  • Yoruba (Nigeria)G;G 58% G;T 36% T;T 6%
  • African ancestry (Southwest US)G;G 70% G;T 26% T;T 4%
  • Chinese (Denver)G;G 67% G;T 29% T;T 4%
  • Gujarati IndianG;G 65% G;T 33% T;T 2%
  • Luhya (Kenya)G;G 65% G;T 30% T;T 5%
  • Mexican ancestry (Los Angeles)G;G 70% G;T 26% T;T 4%
  • Maasai (Kenya)G;G 82% G;T 17% T;T <1%
  • TuscanG;G 82% G;T 18% T;T 0%

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 450 words

Two SNPs from chromosome 4q25, rs2200733 and rs10033464, were found to be associated with atrial fibrillation in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x. In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, rs10033464 was associated with cardioembolic stroke (CES) (odds ratio 1.27, p = 6.1 x 10e-4). rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation. Common variants in KCNN3 are associated with lone atrial fibrillation. Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology. Lone AF - etiologic factors and genetic insights into pathophysiolgy.

G;G

This is the normal version which makes the heart form properly and makes people slightly less likely to get Atrial Fibrillation (quivering of the top chambers of the heart caused by chaotic electrical signals) and less likely to have a cardioembolic stroke (blocked blood flow to the brain). But also check the other SNP nearby (rs2200733) which affects Atrial Fibrillation even more. 23andMe gave this a 4 star confidence rating as it has been heavily studied. It has been confirmed in Europeans.

G;T

This is one copy of a mutant version (and one of the normal version) which slightly affects the formation of the heart and makes people slightly more likely to get Atrial Fibrillation (quivering of the top chambers of the heart caused by chaotic electrical signals) and slightly more likely to have a cardioembolic stroke (blocked blood flow to the brain). But also check the other SNP nearby (rs2200733) which affects Atrial Fibrillation even more. 23andMe gave this a 4 star confidence rating as it has been heavily studied. It has been confirmed in Europeans.

T;T

Two copies of the mutant version which makes affects the formation of the heart and makes people more likely to get Atrial Fibrillation (quivering of the top chambers of the heart caused by chaotic electrical signals) and more likely to have a cardioembolic stroke (blocked blood flow to the brain). But also check the other SNP nearby (rs2200733) which affects Atrial Fibrillation even more. 23andMe gave this a 4 star confidence rating as it has been heavily studied. It has been confirmed in Europeans.

Source and license

Adapted from rs10033464 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.