rs3783799

A SNP in the PRKCH gene on chromosome 14. Its most notable genotype is T;T: 1.4x increased risk for stroke

Gene
PRKCH
Location
Chr 1461,452,498 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
6%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot rated1.4x increased risk for strokeTypical · 0.02% of people
  2. C;TNot rated1.4x increased risk for strokeTypical · 0.017% of people
  3. C;CGoodnormal riskTypical · 0.081% of people

SNPedia records rs3783799 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T 2% C;T 17% C;C 81%
  • European ancestry (Utah)T;T 0% C;T 2% C;C 99%
  • Han Chinese (Beijing)T;T 2% C;T 31% C;C 67%
  • Japanese (Tokyo)T;T 7% C;T 36% C;C 58%
  • Yoruba (Nigeria)T;T 0% C;T 0% C;C 100%

Conditions, medicines and genes

Other PRKCH SNPs

All PRKCH SNPs

Notes

From SNPedia

Notes

A common SNP only in Asian populations, this SNP and a close neighbor also in PRKCH gene, rs3783799, have been associated with higher risk for subcortical silent brain infarction, a common form of stroke. The odds ratio for carriers of a risk allele is 1.27 (CI: 1.09-1.48, p=0.0026) compared to individuals homozygous for the non-risk allele, based on studies of ~300 Japanese patients. Association of PRKCH gene with lacunar infarction in a local Chinese Han population.

Source and license

Adapted from rs3783799 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.