rs1401296

A SNP in the LOC105373608 gene on chromosome 2. Its most notable genotype is C;T.

Gene
LOC105373608
Location
Chr 2127,431,732 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;TMost notableNot ratedNo summary available.Typical · 0.047% of people

On SNPedia: (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;T 47%
  • European ancestry (Utah)C;T 40%
  • Han Chinese (Beijing)C;T 58%
  • Japanese (Tokyo)C;T 57%
  • Yoruba (Nigeria)C;T 32%

Conditions, medicines and genes

Notes

From SNPedia

Notes

linked to Cardiovascular Events Several CVD risk variants were identified: In women, the combination of F5 rs7542281 × THBD rs1042580, together with three single F5 SNPs, was associated with CVD events. Among men, PROC rs1041296, when combined with either ICAM1 rs5030341 or F5 rs2269648, was associated with total mortality. As a single variant, PROC rs1401296, together with the F5 Leiden mutation, was associated with ischemic stroke events.

Source and license

Adapted from rs1401296 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.