rs10757278

This SNP, rs10757278, is one of several clustered together in a region of chromosome 9 that has been linked to increased risk for heart disease and potentially diabetes. The overall estimate of heart disease cases that may involve this SNP (or related ones nearby) is said to be 20-30%. The risk allele, rs10757278(G), shows an increased association for myocardial infarctions ("MI"; heart attacks) both in general and more specifically in so-called early onset MI. The odds ratio relative to rs10757278(A:A) "noncarrier" individuals for rs10757278(G;G) individuals is 1.64 (CI: 1.47-1.82), and for carriers of one risk allele, i.e. rs10757278(A;G) individuals, 1.26 (CI: 1.16-1.36). For early onset MI, the odds are slightly higher; homozygote rs10757278(G;G) individuals have an odds ratio of 2.02 (CI: 1.72-2.36), heterozygote rs10757278(A;G) individuals 1.49 (CI: 1.31-1.69) compared to noncarriers. To put it another way, men under the age of 50 and women under the age of 60 who are rs10757278(G:G) individuals have about twice the risk of having a heart attack compared to rs10757278(A:A) individuals. Two other SNPs in this region with similar reports are rs10757274 and rs2383206. In an extension of the research reported above, the rs10757278(G) allele has been found to be associated with stroke as defined by abdominal aortic aneurysm (AAA; odds ratio 1.31, p=1.2x10e-12) and Intracranial Aneurysm (odds ratio 1.29, p=2.5x10e-6), but not with type-2 diabetes. The AA genotype appears to be protective, with 0.77x odds of developing abdominal aortic aneurysm as reported by DeCode. This SNP was also associated with increased risk for coronary artery disease in a Korean population. Also found to be significant in a study of 416 Italian myocardial infarction patients. A study and meta-analysis of 2,000+ Belgians concluded that rs10757278 is associated with increased risk for coronary artery disease but not ischemic cerebrovascular disease. * Note: this SNP and rs1333049 are practically equivalent, with linkage r 2 =1 in HapMap CEU populations coronary artery disease rs1075727 and rs2383206 myocardial infarction rs2383207 and rs10757278 The association remained significant after adjusting for significant clinical covariates (P=0.001 to 0.024). We identified one risk haplotype (GGGG; P=0.017) and one protective haplotype (AAAA; P=0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P=0.001 to 0.024; OR=2.37 to 1.54). Brain Aneurysm in Chinese women no significant breast cancer association at rs1011970, rs10757278 or rs2380205

A;A

This lowers risk of Myocardial Infarction (Heart Attack), other Coronary Heart Disease, brain aneurysm (weakened artery to the brain), and abdominal aortic aneurysm (weakened artery to the abdomen and legs).

A;G

One copy of a SNP that increases risk of Myocardial Infarction (Heart Attack) and other Coronary Heart Disease. It has been shown that regularly eating raw vegetables and fruit can reduce the risk to the same level as people without this SNP. This SNP also has the normal medium risk of abdominal aortic aneurysm (weakened artery to abdomen and legs) or brain aneurysm (weakened artery to brain).

G;G

Two copies of an SNP that increases risk of Myocardial Infarction (Heart Attack) and other Coronary Heart Disease. It has been shown that regularly eating raw vegetables and fruit can reduce the risk to the same level as people without any copies of this SNP. This SNP also increases risk of abdominal aortic aneurysm (weakened artery to the abdomen and legs), and brain aneurysm (weakened artery to the brain).