rs4293393

A SNP in the UMOD gene on chromosome 16. Its most notable genotype is G;G: 0.76x reduced risk of CKD for C allele

Gene
UMOD
Location
Chr 1620,353,266 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGood0.76x reduced risk of CKD for C alleleTypical · 0.03% of people
  2. A;GGoodNo summary available.Typical · 0.030% of people
  3. A;ABad1.25x Increased Risk of CKD for T allele in Icelandic studyTypical · 0.067% of people

SNPedia records rs4293393 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 3% A;G 30% A;A 67%
  • European ancestry (Utah)G;G 3% A;G 30% A;A 67%
  • Han Chinese (Beijing)G;G <1% A;G 20% A;A 79%
  • Japanese (Tokyo)G;G 0% A;G 9% A;A 91%
  • Yoruba (Nigeria)G;G 5% A;G 33% A;A 63%
  • African ancestry (Southwest US)G;G 2% A;G 42% A;A 56%
  • Chinese (Denver)G;G 0% A;G 10% A;A 90%
  • Gujarati IndianG;G 7% A;G 35% A;A 58%
  • Luhya (Kenya)G;G <1% A;G 43% A;A 56%
  • Mexican ancestry (Los Angeles)G;G 2% A;G 36% A;A 62%
  • Maasai (Kenya)G;G 9% A;G 42% A;A 49%
  • TuscanG;G 3% A;G 27% A;A 71%

Conditions, medicines and genes

Other UMOD SNPs

All UMOD SNPs

Notes

From SNPedia

Notes

23andMe blog each G at rs4293393 decreased the odds of chronic kidney disease by 24%. Approximately 18% of people with European ancestry have at least one G at this SNP. nature.com DeCode reports that the T allele of rs4293393 is associated with kidney stones and chronic kidney disease. decodeyou.com This SNP may also be associated with susceptibility to gout, hypertension, and diabetes.

Source and license

Adapted from rs4293393 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.