rs13333226

A SNP in the UMOD gene on chromosome 16. Its most notable genotype is G;G: ~15-20% lower risk for hypertension or cardiovascular events

Gene
UMOD
Location
Chr 1620,354,332 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
20%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABadcommon but slightly higher risk for hypertensionMinor · 1.062% of people
  2. A;GGoodslightly lower risk for hypertensionMinor · 1.133% of people
  3. G;GMost notableGood~15-20% lower risk for hypertension or cardiovascular eventsMinor · 1.25% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 62% A;G 33% G;G 5%
  • European ancestry (Utah)A;A 67% A;G 30% G;G 3%
  • Han Chinese (Beijing)A;A 79% A;G 20% G;G <1%
  • Japanese (Tokyo)A;A 91% A;G 9% G;G 0%
  • Yoruba (Nigeria)A;A 38% A;G 47% G;G 15%
  • African ancestry (Southwest US)A;A 40% A;G 53% G;G 7%
  • Chinese (Denver)A;A 90% A;G 10% G;G 0%
  • Gujarati IndianA;A 57% A;G 35% G;G 8%
  • Luhya (Kenya)A;A 47% A;G 44% G;G 9%
  • Mexican ancestry (Los Angeles)A;A 62% A;G 36% G;G 2%
  • Maasai (Kenya)A;A 39% A;G 50% G;G 12%
  • TuscanA;A 71% A;G 27% G;G 3%

Other UMOD SNPs

All UMOD SNPs

Notes

From SNPedia

Notes

rs13333226 is a SNP in the 5' region of uromodulin UMOD gene. A large GWAS study ultimately totaling over 20,000 cases and almost as many controls concluded that, compared to the far more common allele, the rarer rs13333226(G) allele is associated with a (slightly) lower risk of hypertension (odds ratio 0.87, CI: 0.84-0.91) as well as a 7.7% reduction per allele for risk of cardiovascular events after adjusting for age, sex, BMI, and smoking status (hazard ratio?0.923, CI: 0.860-0.991; p?=?0.027). High Blood Pressure (Hypertension) Kidney Disease

Source and license

Adapted from rs13333226 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.