rs1057910(C;C)

CYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugs

Magnitude
4.0Very important
Repute
Bad
Frequency
<1%Average of 9 populations
On SNPedia
rs1057910(C;C)
Gene
CYP2C9

Frequency

Share of people with C;C in each HapMap population.

  • Gujarati Indian1%
  • European ancestry (Utah)0%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%
  • African ancestry (Southwest US)0%
  • Chinese (Denver)0%
  • Mexican ancestry (Los Angeles)0%
  • Tuscan0%

Other genotypes of rs1057910

  1. A;AGoodnormal; no effect on warfarin metabolismTypical · 0.190% of people
  2. A;CBadCYP2C9*3 carrier; average 40% reduction in warfarin metabolismWorth knowing · 2.510% of people

All about rs1057910

Notes

From SNPedia

* 12x risk of severe cutaneous adverse reactions when taking antiepileptic drug phenytoin. * rs1057910(C;C) genotypes may clear drugs like celecoxib (trade name Celebrex) twice as slowly as rs1057910(A;A) genotypes; the rs1057910(A;C) genotypes are in-between clearance rates. Lower clearance rates will lead to higher internal concentrations of the drug. It is not clear whether this could lead to increased efficacy and/or increased side effects. * rs1057910(C;C) genotypes are poor metabolizers of tolbutamide, a sulfonylurea hypoglycemic drug used in the treatment of diabetes. * rs1057910(C;C) genotypes are poor metabolizers of phenytoin, a drug used to treat epilepsy, and therefore tend to need lower doses. * rs1057910(C;C) genotypes are poor metabolizers of glipizide, a second generation sulfonylurea drug structurally similar to tolbutamide and also used as an oral hypoglycemic agent. * rs1057910(C;C) genotypes are poor metabolizers of warfarin, and therefore unusually sensitive.

References

Source and license

Adapted from rs1057910(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.