rs7529229
A SNP in the IL6R gene on chromosome 1. Its most notable genotype is C;C: 2.5x higher risk of multiple myeloma than AA
- Gene
- IL6R
- Location
- Chr 1154,448,302 (GRCh38)
- Highest magnitude
- 1.4Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 46%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 27% T;T 28%
- European ancestry (Utah)C;C 14% T;T 43%
- Han Chinese (Beijing)C;C 15% T;T 37%
- Japanese (Tokyo)C;C 14% T;T 43%
- Yoruba (Nigeria)C;C 51% T;T 3%
- African ancestry (Southwest US)C;C 35% T;T 19%
- Chinese (Denver)C;C 22% T;T 34%
- Gujarati IndianC;C 3% T;T 49%
- Luhya (Kenya)C;C 49% T;T 6%
- Mexican ancestry (Los Angeles)C;C 33% T;T 28%
- Maasai (Kenya)C;C 45% T;T 12%
- TuscanC;C 16% T;T 35%
Related
Conditions, medicines and genes
Other IL6R SNPs
Notes
From SNPedia
Notes
multiple myeloma *rs1801278 [C/T versus C/C genotypes; OR, 4.3; 95% confidence interval (CI), 1.5-12.1] *rs6684439 (T/T versus C/C; OR, 2.9; 95% CI, 1.2-7.0) *rs7529229 (C/C versus T/T; OR, 2.5; 95% CI, 1.1-6.0) *rs8192284 (C/C versus A/A; OR, 2.5, 95% CI, 1.1-6.0)
C;C
This SNP is in strong LD with rs1801278, rs6684439, and rs8192284 and likely represent the same risk allele of the IL-6 receptor gene.
T;T
This SNP is in strong LD with rs1801278, rs6684439, and rs8192284 and likely to represent the same risk allele of the IL-6 receptor gene.
Source and license
Adapted from rs7529229 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.