rs878853647
A SNP in the CDKN2A gene on chromosome 9. Its most notable genotype is C;G: Malignant melanoma predisposing mutation
- Gene
- CDKN2A
- Location
- Chr 921,971,099 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- Not on consumer chips
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;GMost notableBadMalignant melanoma predisposing mutation
- C;CGoodcommon in clinvar
SNPedia records rs878853647 on the minus strand: (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CDKN2A SNPs
- rs1800586A;CPancreatic cancer/Melanoma SyndromeVery important
- rs36204594G;TPancreatic cancer/Melanoma SyndromeVery important
- rs104894098A;TPancreatic cancer/Melanoma SyndromeVery important
- rs121913381A;CPancreatic cancer/Melanoma SyndromeVery important
- rs199907548A;CPancreatic cancer/Melanoma SyndromeVery important
- rs587782206-;TGGCPancreatic cancer/Melanoma SyndromeVery important
- rs730881672-;CTPancreatic cancer/Melanoma SyndromeVery important
- rs730881675-;ACCCGTGCACGACGPancreatic cancer/Melanoma SyndromeVery important
Notes
From SNPedia
Notes
rs878853647, also known as c.260G>C, p.Arg87Pro and R87P, is a rare variant in the CDKN2A gene on chromosome 9. The rs878853647(C) variant is considered pathogenic in ClinVar for a dominantly inherited form of melanoma.
C;G
see rs878853647
Source and license
Adapted from rs878853647 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.