rs1800586
A SNP in the CDKN2A gene on chromosome 9. Its most notable genotype is A;C: Pancreatic cancer/Melanoma Syndrome
- Gene
- CDKN2A
- Location
- Chr 921,974,861 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- A;CMost notableBadPancreatic cancer/Melanoma Syndrome
SNPedia records rs1800586 on the minus strand: (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CDKN2A SNPs
- rs36204594G;TPancreatic cancer/Melanoma SyndromeVery important
- rs104894098A;TPancreatic cancer/Melanoma SyndromeVery important
- rs121913381A;CPancreatic cancer/Melanoma SyndromeVery important
- rs199907548A;CPancreatic cancer/Melanoma SyndromeVery important
- rs587782206-;TGGCPancreatic cancer/Melanoma SyndromeVery important
- rs730881672-;CTPancreatic cancer/Melanoma SyndromeVery important
- rs730881675-;ACCCGTGCACGACGPancreatic cancer/Melanoma SyndromeVery important
- rs730881677C;GPancreatic cancer/Melanoma SyndromeVery important
Notes
From SNPedia
Notes
rs1800586, also known as c.-34G>T, represents a rare mutation in the CDKN2A gene on chromosome 9. The rs1800586(T) allele is considered pathogenic in a dominant manner for malignant melanoma, based on sources in ClinVar and elsewhere. CDKN2A mutations may also predispose to other types of cancer.,
Source and license
Adapted from rs1800586 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.