rs587776650
A SNP in the NBN gene on chromosome 8. Its most notable genotype is -;-: Nijmegen breakage syndrome
- Gene
- NBN
- Location
- Chr 889,971,214 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableBadNijmegen breakage syndrome
- -;TTTGTBadhigher risk for several cancers; carrier for Nijmegen breakage syndrome allele
- TTTGT;TTTGTGoodcommon/normal
On SNPedia: (-;-), (-;TTTGT), (TTTGT;TTTGT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 140 words
rs587776650, also known as c.657_661delACAAA, 657del5 and p.Lys219Asnfs, is a mutation in the NBN gene on chromosome 8. Carriers of one rs587776650(-) allele are at increased risk for several types of cancer, including breast cancer (odd ratio ~2.5), lymphoma (OR 2.9), and prostate cancer (OR ~6). It may also significantly increase risk for melanoma and Non-Hodgkin Lymphoma. Double mutations (i.e. recessive or compound heterozygote) in the NBN gene cause Nijmegen breakage syndrome. A meta-analysis of ten studies totaling over 25,000 subjects associated rs587776650(-) with increased breast cancer risk (OR 2.66, CI: 1.82-3.90, p < 0.001). See also OMIM 602667.0001 Nijmegen breakage syndrome This mutation is believed to be represented within 23andMe data as i5012770.
-;-
see mention at rs587776650
-;TTTGT
see discussion at rs587776650
Source and license
Adapted from rs587776650 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.