rs1805794
A SNP in the NBN gene on chromosome 8. Its most notable genotype is C;C: common in clinvar
- Gene
- NBN
- Location
- Chr 889,978,251 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 33%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 45%
- European ancestry (Utah)C;C 50%
- Han Chinese (Beijing)C;C 29%
- Japanese (Tokyo)C;C 33%
- Yoruba (Nigeria)C;C 70%
- African ancestry (Southwest US)C;C 63%
- Chinese (Denver)C;C 36%
- Gujarati IndianC;C 27%
- Luhya (Kenya)C;C 57%
- Mexican ancestry (Los Angeles)C;C 41%
- Maasai (Kenya)C;C 48%
- TuscanC;C 46%
Related
Notes
From SNPedia
Show notes, about 380 words
Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools. Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions. Analysis of variants in DNA damage signalling genes in bladder cancer. Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway. Association and interactions between DNA repair gene polymorphisms and adult glioma. Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer. Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer. Association between the NBS1 E185Q polymorphism and cancer risk: a meta-analysis. Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2 French Canadian families with high risk of breast cancer. Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51. Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer. The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in Taiwanese patients. Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID. Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population. DNA Repair System and Prostate Cancer Progression: The Role of NBS1 Polymorphism (rs1805794). Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma.
Source and license
Adapted from rs1805794 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.