rs910873(A;G)

1.7x increased risk of melanoma; increased risk of squamous cell carcinoma

Magnitude
3.0Important
Repute
Bad
Frequency
4%Average of 7 populations
On SNPedia
rs910873(A;G)
Gene
PIGU

Frequency

Share of people with A;G in each HapMap population.

  • European ancestry (Utah)15%
  • Tuscan6%
  • Mexican ancestry (Los Angeles)3%
  • Gujarati Indian2%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%

Other genotypes of rs910873

  1. A;AMost notableBad3x increased risk of melanomaVery important · 4.0<1% of people
  2. G;GGoodnormalTypical · 0.096% of people

All about rs910873

Notes

From SNPedia

You carry one allele associated with an increased risk for melanoma and squamous cell carcinoma. Watch for unusual or expanding skin growths or moles, always use SPF 30, and avoid the direct sun between 10am and 4pm. In a nested case-control study based on the Nurses Health Study, the correlation between rs910873 and skin cancer was examined in a Caucasian population. This study included 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCS) cases, and 870 age-matched controls. rs910873 was found to be significantly associated with increased risks of melanoma and SCC (but not BSC) in both additive (additive OR for melanoma, 1.67; 95% CI, 1.19–2.34; additive OR for SCC, 1.51; 95% CI, 1.09-2.10) and dominant models (G;A or A;A; dominant OR for melanoma, 1.81; 95% CI, 1.23-2.67; dominant OR for SCC, 1.70; 95% CI, 1.19-2.43). P for trends = 0.01 and 0.003 for melanoma and SCC, respectively.

Source and license

Adapted from rs910873(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.