rs910873

A total of 2,019 cutaneous melanoma cases and 2,105 controls (Australians of European descent) were included in this genome-wide pooling association study. Using pooling, a new melanoma risk locus was identified on chromosome 20 (rs910873 and rs1885120; combined P 40 OR, 1.30 (95% CI, 1.00-1.69)). This study, which was conducted within the Nurses' Health Study, included 492 cases of non-melanoma skin cancer (NMSC; basal cell and squamous cell carcinomas) and 619 controls. The subjects were all Caucasian women, and the follow-up period was 28 years. rs910873, an ASIP gene-related SNP, was found to be associated with an increased number of NMSCs: age-adjusted odds ratio (OR): 1.43 (95% CI, 1.09–1.89) (p = 0.01). A pooled analysis of 1507 NMSC cases and 4335 controls confirmed that rs910873 was associated with an increased risk of NMSC (age-adjusted OR, 1.35; 95% CI, 1.20-1.53; p = 8.4E-7). Similarly to the study mentioned above () this nested case-control study was based on the Nurses Health Study (NHS) and examined the correlation between rs910873 and skin cancer in a Caucasian population. This study included 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCS) cases, and 870 age-matched controls. rs910873 was found to be significantly associated with increased risks of melanoma and SCC (but not BSC) in both additive (additive OR for melanoma, 1.67; 95% CI, 1.19–2.34; additive OR for SCC, 1.51; 95% CI, 1.09-2.10) and dominant models (G;A or A;A; dominant OR for melanoma, 1.81; 95% CI, 1.23-2.67; dominant OR for SCC, 1.70; 95% CI, 1.19-2.43). P for trends = 0.01 and 0.003 for melanoma and SCC, respectively.

A;A

Two copies of the allele associated with increased risk of melanoma. Watch for unusual skin growths or moles.

A;G

You carry one allele associated with an increased risk for melanoma and squamous cell carcinoma. Watch for unusual or expanding skin growths or moles, always use SPF 30, and avoid the direct sun between 10am and 4pm. In a nested case-control study based on the Nurses Health Study, the correlation between rs910873 and skin cancer was examined in a Caucasian population. This study included 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCS) cases, and 870 age-matched controls. rs910873 was found to be significantly associated with increased risks of melanoma and SCC (but not BSC) in both additive (additive OR for melanoma, 1.67; 95% CI, 1.19–2.34; additive OR for SCC, 1.51; 95% CI, 1.09-2.10) and dominant models (G;A or A;A; dominant OR for melanoma, 1.81; 95% CI, 1.23-2.67; dominant OR for SCC, 1.70; 95% CI, 1.19-2.43). P for trends = 0.01 and 0.003 for melanoma and SCC, respectively.