rs258322

A SNP in the CDK10 gene on chromosome 16. Its most notable genotype is A;A: 2x increased risk of Melanoma

Gene
CDK10
Location
Chr 1689,689,495 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
27%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2x increased risk of MelanomaImportant · 3.011% of people

SNPedia records rs258322 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 11%
  • European ancestry (Utah)A;A <1%
  • Han Chinese (Beijing)A;A 38%
  • Japanese (Tokyo)A;A 39%
  • Yoruba (Nigeria)A;A 3%
  • African ancestry (Southwest US)A;A 5%
  • Chinese (Denver)A;A 34%
  • Gujarati IndianA;A 1%
  • Luhya (Kenya)A;A 3%
  • Mexican ancestry (Los Angeles)A;A 0%
  • Maasai (Kenya)A;A 1%
  • TuscanA;A 0%

Conditions, medicines and genes

Notes

From SNPedia

Notes

This SNP occurs within CDK10, (cyclin-dependent kinase 10). The T variant has been associated with increased risk of Melanoma (OR=1.67, 95%CI 1.52-1.83) , (OR=2.26, 95%CI 1.32&#8211;3.88) . ==References== Genome-wide association study identifies three loci associated with melanoma risk. 23andMe blog rs258322 A (T in dbSNP): OR 1.67 for Melanoma

Source and license

Adapted from rs258322 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.