rs1393350

A SNP in the TYR gene on chromosome 11. Its most notable genotype is A;A.

Gene
TYR
Location
Chr 1189,277,878 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedNo summary available.Important · 3.02% of people
  2. A;GNot ratedNo summary available.Worth knowing · 2.013% of people
  3. G;GGoodcommon on affy axiom dataTypical · 0.086% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 2% A;G 13% G;G 86%
  • European ancestry (Utah)A;A 8% A;G 29% G;G 63%
  • Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
  • Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • African ancestry (Southwest US)A;A 2% A;G 7% G;G 91%
  • Chinese (Denver)A;A 0% A;G <1% G;G 99%
  • Gujarati IndianA;A 1% A;G 19% G;G 80%
  • Mexican ancestry (Los Angeles)A;A 2% A;G 28% G;G 71%
  • Maasai (Kenya)A;A 0% A;G 3% G;G 97%
  • TuscanA;A 4% A;G 42% G;G 54%

Conditions, medicines and genes

Other TYR SNPs

All TYR SNPs

Notes

From SNPedia

Show notes, about 130 words

23andMe blog rs1393350 A 1.29 Melanoma rs1393350 increases susceptibility to Blond rather than brown hair 1.29 times for carriers of the A allele rs1393350 increases susceptibility to Blue rather than green eyes 1.52 times for carriers of the A allele rs1393350 increases susceptibility to Skin sensitivity to sun 1.26 times for carriers of the A allele A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. Digital quantification of human eye color highlights genetic association of three new loci.

A;A

more sensitive to sunlight, higher risk of melanoma, more likely to have blue eyes and numerous other features common to light skinned caucasians

Source and license

Adapted from rs1393350 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.