rs1799989

A SNP in the TYR gene on chromosome 11. Its most notable genotype is A;C: benign most likely

Gene
TYR
Location
Chr 1189,177,755 (GRCh38)
Highest magnitude
0.5Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;CMost notableBadbenign most likelyTypical · 0.530% of people
  2. C;CGoodcommon in clinvarTypical · 0.064% of people

On SNPedia: (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;C 30% C;C 64%
  • European ancestry (Utah)A;C 18% C;C 81%
  • Han Chinese (Beijing)A;C 18% C;C 80%
  • Japanese (Tokyo)A;C 24% C;C 73%
  • Yoruba (Nigeria)A;C 39% C;C 50%
  • African ancestry (Southwest US)A;C 30% C;C 61%
  • Chinese (Denver)A;C 19% C;C 79%
  • Gujarati IndianA;C 38% C;C 59%
  • Luhya (Kenya)A;C 44% C;C 39%
  • Mexican ancestry (Los Angeles)A;C 36% C;C 62%
  • Maasai (Kenya)A;C 44% C;C 39%
  • TuscanA;C 19% C;C 80%

Conditions, medicines and genes

Other TYR SNPs

All TYR SNPs

Notes

From SNPedia

Notes

among 120 (likely Japanese) first-episode neuroleptic-naive schizophrenics treated with risperidone genotyped for 30 variants in misc. dopamine and serotonin (receptors and otherwise) two SNPs in DRD2 (rs1799989 and rs1800497) and two SNPs in AKT1 (rs3803300 and rs2494732) were significant predictors of treatment response to risperidone

A;C

although reported as an albinism allele, the frequency of this variant seems far too high in most populations to give credence to this.

Source and license

Adapted from rs1799989 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.