rs1126809
A SNP in the TYR gene on chromosome 11. Its most notable genotype is A;A: slight increase in skin cancer risk
- Gene
- TYR
- Location
- Chr 1189,284,793 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 11%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedslight increase in skin cancer risk
- A;GGoodslight increase in skin cancer risk
- G;GGoodnormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 1% A;G 8% G;G 90%
- European ancestry (Utah)A;A 5% A;G 34% G;G 62%
- Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
- Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
- Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs1126809 is a SNP in the TYR tyrosinase gene. This SNP is also known as R402Q (or, 1205G>A) based on the amino acid change at position 402 from an arginine (R) to a glutamine (Q). The rs1126809(G) allele encodes the more common (R)/arginine, while the variant rs1126809(A) allele encodes the (Q)/glutamine. rs1126809(A) has previously been shown to affect eye color and sun sensitivity. Based on a study of 4,000+ skin cancer patients, it also conferred increased risk of cutaneous malignant melanoma (odds ratio 1.21, p = 2.8 x 10 -7 ) and basal cell carcinoma (odds ratio 1.14, p = 6.1 x 10 -4 ). rs1126809 is not associated with albinism.
Source and license
Adapted from rs1126809 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.