rs768966657
A SNP in the CDKN2A gene on chromosome 9. Its most notable genotype is -;GAC: For those w/ cancer, a slightly worse prognosis; also, slightly increased melanoma risk
- Gene
- CDKN2A
- Location
- Chr 921,971,021 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Goodcommon/normal
- -;GACMost notableBadFor those w/ cancer, a slightly worse prognosis; also, slightly increased melanoma risk
On SNPedia: (-;-), (-;GAC). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CDKN2A SNPs
- rs1800586A;CPancreatic cancer/Melanoma SyndromeVery important
- rs36204594G;TPancreatic cancer/Melanoma SyndromeVery important
- rs104894098A;TPancreatic cancer/Melanoma SyndromeVery important
- rs121913381A;CPancreatic cancer/Melanoma SyndromeVery important
- rs199907548A;CPancreatic cancer/Melanoma SyndromeVery important
- rs587782206-;TGGCPancreatic cancer/Melanoma SyndromeVery important
- rs730881672-;CTPancreatic cancer/Melanoma SyndromeVery important
- rs730881675-;ACCCGTGCACGACGPancreatic cancer/Melanoma SyndromeVery important
Notes
From SNPedia
Notes
rs768966657, also known as c.335_337dupGTC, p.Arg112_Leu113insArg and Argdup112, represents a mutation in the CDKN2A gene on chromosome 9. This appears to the mutation described by Borg et al. as a founder mutation predisposing to melanoma from ~2000 years ago from southern Sweden. More recently, cancer patients who have a CDKN2A Argdup112 mutation are reported to have a worse survival than non-carriers for both melanoma (hazard ratio 2.5, CI: 1.49 - 4.21) and especially non-melanoma cancers (HR 7.77, CI: 3.65 - 16.51). news
-;GAC
see discussion at rs768966657
Source and license
Adapted from rs768966657 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.