rs746834149
A SNP in the CDKN2A gene on chromosome 9. Its most notable genotype is C;T: Malignant melanoma predisposing mutation
- Gene
- CDKN2A
- Location
- Chr 921,974,724 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CDKN2A SNPs
- rs1800586A;CPancreatic cancer/Melanoma SyndromeVery important
- rs36204594G;TPancreatic cancer/Melanoma SyndromeVery important
- rs104894098A;TPancreatic cancer/Melanoma SyndromeVery important
- rs121913381A;CPancreatic cancer/Melanoma SyndromeVery important
- rs199907548A;CPancreatic cancer/Melanoma SyndromeVery important
- rs587782206-;TGGCPancreatic cancer/Melanoma SyndromeVery important
- rs730881672-;CTPancreatic cancer/Melanoma SyndromeVery important
- rs730881675-;ACCCGTGCACGACGPancreatic cancer/Melanoma SyndromeVery important
Notes
From SNPedia
Notes
rs746834149, also known as c.104G>A, p.Gly35Ala and G35A, represents a rare mutation in the CDKN2A gene on chromosome 9. Note that dbSNP shows the mutation in plus orientation as C>T, but ClinVar and a paper cited below cite evidence for the observed mutation in minus orientation as G>A. The rs746834149(A) allele is considered pathogenic in a dominant manner for malignant melanoma, based on sources in ClinVar and elsewhere. CDKN2A mutations may also predispose to other types of cancer.,
C;T
see rs746834149
Source and license
Adapted from rs746834149 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.