rs1801131(G;T)

Possibly impaired folate metabolism

Magnitude
2.1Worth knowing
Repute
Bad
Frequency
34%Average of 11 populations
On SNPedia
rs1801131(A;C)Minus strand
Gene
MTHFR

Frequency

Share of people with G;T in each HapMap population.

  • Gujarati Indian46%
  • European ancestry (Utah)45%
  • Tuscan36%
  • Maasai (Kenya)35%
  • Han Chinese (Beijing)34%
  • Japanese (Tokyo)34%
  • African ancestry (Southwest US)33%
  • Mexican ancestry (Los Angeles)31%
  • Chinese (Denver)28%
  • Luhya (Kenya)27%
  • Yoruba (Nigeria)23%

Other genotypes of rs1801131

  1. T;TGoodmost common genotypeTypical · 0.060% of people
  2. G;GMost notableBadNumber of risks. Complex.Worth knowing · 2.57% of people

All about rs1801131

Notes

From SNPedia

MTHFR rs1801131 (C) or MTHFR A1298C is a mutation in the folate pathway, specifically in the enzyme involved in converting 5-methylfolate (5MTHF) to tetrahydrofolate (THF). Defects in folate metabolism can increase the risk of neural tube defects and possibly contribute to risk of stroke / heart attack. Unlike rs1801133 or MTHFR C677T, this mutation does not lead to elevated homocysteine levels, however some studies have suggested that there may be a synergistic effect in individuals heterozygous for both mutations.

References

Source and license

Adapted from rs1801131(A;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.