rs9642880

A SNP in the CASC11 gene on chromosome 8. Its most notable genotype is G;G: Slightly lower risk of Bladder Cancer.

Gene
CASC11
Location
Chr 8127,705,823 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
50%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodSlightly lower risk of Bladder Cancer.Worth knowing · 2.025% of people
  2. G;TBad1.2x increased bladder cancer riskMinor · 1.541% of people
  3. T;TBad1.5x increased bladder cancer riskWorth knowing · 2.034% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 25% G;T 41% T;T 34%
  • European ancestry (Utah)G;G 35% G;T 44% T;T 20%
  • Han Chinese (Beijing)G;G 47% G;T 43% T;T 10%
  • Japanese (Tokyo)G;G 54% G;T 36% T;T 11%
  • Yoruba (Nigeria)G;G 3% G;T 35% T;T 61%
  • African ancestry (Southwest US)G;G 7% G;T 33% T;T 60%
  • Chinese (Denver)G;G 50% G;T 35% T;T 16%
  • Gujarati IndianG;G 19% G;T 39% T;T 43%
  • Luhya (Kenya)G;G 2% G;T 35% T;T 64%
  • Mexican ancestry (Los Angeles)G;G 19% G;T 55% T;T 26%
  • Maasai (Kenya)G;G 10% G;T 43% T;T 47%
  • TuscanG;G 29% G;T 54% T;T 17%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 190 words

rs9642880 is a SNP located in chromosome region 8q24, a region that has been linked to prostate, breast, and colon cancer. A study ultimately totaling over 4,000 bladder cancer patients of European ancestry (and 40,000 controls) concluded that individuals carrying two copies of rs9642880(T) were at 1.49x increased risk (allele-specific odds ratio = 1.22, p = 9 x 10e-12) for the disease. This SNP was not associated, however, with risk for prostate, breast, or colon cancer. Another study in Chinese populations found similar results in regard to bladder cancer. rs9642880(T;T) estimated risk of developing 1.49 times that of noncarriers. 1,803 urinary bladder cancer cases and 34,336 controls. No association with prostate, colorectal and breast cancers. In contrast to GSTM1 SNPs, the rs9642880(T) was only associated with increased risk for bladder cancer in cases not selected based on exposure to bladder carcinogens such as aromatic amines and polycyclic aromatic hydrocarbons, based on an analysis of 515 bladder cancer cases and 893 controls where the quality and quantity of occupational exposure to bladder carcinogens was documented.

Source and license

Adapted from rs9642880 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.