rs2736098

A SNP in the TERT gene on chromosome 5. Its most notable genotype is T;T: slightly increased risk for several types of cancers

Gene
TERT
Location
Chr 51,293,971 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadslightly increased risk for several types of cancersTypical · 0.09% of people
  2. C;TBadslightly increased risk for several types of cancersTypical · 0.036% of people
  3. C;CGoodnormalTypical · 0.055% of people

SNPedia records rs2736098 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T 9% C;T 36% C;C 55%
  • European ancestry (Utah)T;T 11% C;T 52% C;C 37%
  • Han Chinese (Beijing)T;T 22% C;T 38% C;C 40%
  • Japanese (Tokyo)T;T 5% C;T 41% C;C 55%
  • Yoruba (Nigeria)T;T 0% C;T 11% C;C 89%

Conditions, medicines and genes

Other TERT SNPs

All TERT SNPs

Notes

From SNPedia

Notes

A 2014 study "Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer" of 7,683 European cases and 14,397 controls found the minor allele rs2736098(A) in TERT (telomerase reverse transcriptase) conferring a protective effect of statistically genome-wide significance (per-allele odds ratio (OR) = 0.80, 95% confidence interval (CI) 0.76-0.85, P = 9.8E-14) against Pancreatic cancer. For example indicates the A allele might be risk-factor for Asians but protective for Europeans. 23andMe blog rs2736098 and rs401681 linked to many cancers

Source and license

Adapted from rs2736098 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.