rs12304921

A SNP in the SLC11A2 gene on chromosome 12. Its most notable genotype is A;A: normal

Gene
SLC11A2
Location
Chr 1250,963,759 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormalTypical · 0.054% of people
  2. A;GBad2.5x risk type 2 diabetesTypical · 0.036% of people
  3. G;GBad1.9x risk type 2 diabetesTypical · 0.09% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 54% A;G 36% G;G 9%
  • European ancestry (Utah)A;A 71% A;G 27% G;G 2%
  • Han Chinese (Beijing)A;A 27% A;G 46% G;G 27%
  • Japanese (Tokyo)A;A 26% A;G 54% G;G 20%
  • Yoruba (Nigeria)A;A 75% A;G 21% G;G 4%
  • African ancestry (Southwest US)A;A 60% A;G 36% G;G 4%
  • Chinese (Denver)A;A 24% A;G 52% G;G 24%
  • Gujarati IndianA;A 39% A;G 51% G;G 11%
  • Luhya (Kenya)A;A 60% A;G 38% G;G 2%
  • Mexican ancestry (Los Angeles)A;A 76% A;G 24% G;G 0%
  • Maasai (Kenya)A;A 61% A;G 30% G;G 9%
  • TuscanA;A 81% A;G 18% G;G 1%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs12304921 has been reported in a large study to be associated with type-2 diabetes. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 2.50 (CI 1.53-4.09), and for homozygotes, 1.94 (CI 1.20-3.15).

Source and license

Adapted from rs12304921 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.