rs1470579

A SNP in the IGF2BP2 gene on chromosome 3. Its most notable genotype is A;A: normal

Gene
IGF2BP2
Location
Chr 3185,811,292 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
41%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.033% of people
  2. A;CBad1.2x increased risk for type-2 diabetesTypical · 0.037% of people
  3. C;CBad1.2x increased risk for type-2 diabetesTypical · 0.029% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 33% A;C 37% C;C 29%
  • European ancestry (Utah)A;A 50% A;C 40% C;C 10%
  • Han Chinese (Beijing)A;A 57% A;C 40% C;C 4%
  • Japanese (Tokyo)A;A 45% A;C 45% C;C 10%
  • Yoruba (Nigeria)A;A 2% A;C 25% C;C 73%
  • African ancestry (Southwest US)A;A 13% A;C 41% C;C 46%
  • Chinese (Denver)A;A 52% A;C 39% C;C 8%
  • Gujarati IndianA;A 24% A;C 54% C;C 23%
  • Luhya (Kenya)A;A 3% A;C 23% C;C 75%
  • Mexican ancestry (Los Angeles)A;A 59% A;C 36% C;C 5%
  • Maasai (Kenya)A;A 4% A;C 39% C;C 57%
  • TuscanA;A 59% A;C 30% C;C 11%

Conditions, medicines and genes

Other IGF2BP2 SNPs

All IGF2BP2 SNPs

Notes

From SNPedia

Show notes, about 190 words

rs1470579 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.18 (CI: 1.07-1.31, p = 8.3 x 10e-4) T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for *CDKAL1 (OR(rs7756992) = 1.30[1.19-1.42], P = 2.3x10(-9)) *CDKN2A/2B (OR(rs10811661) = 0.74[0.66-0.82], P = 3.5x10(-8)) *IGFBP2 (OR(rs1470579) = 1.17[1.07-1.27], P = 0.0003) SNPs. T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 rs7903146 SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24) Neither rs4402960 or rs1470579 were found to be associated with type-2 diabetes in a study of 3,000 French Caucasians. This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese). Note: rs1470579 is fairly tightly linked (r2=0.87) with another IGF2BP2 gene SNP also associated with type-2 diabetes, rs4402960

Source and license

Adapted from rs1470579 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.