rs4402960

A SNP in the IGF2BP2 gene on chromosome 3. Its most notable genotype is T;T: 1.2x increased risk for type-2 diabetes, 1.5x risk for gestational diabetes

Gene
IGF2BP2
Location
Chr 3185,793,899 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodnormalTypical · 0.040% of people
  2. G;TBad1.2x increased risk for type-2 diabetes, ~1x risk for gestational diabetesWorth knowing · 2.044% of people
  3. T;TMost notableBad1.2x increased risk for type-2 diabetes, 1.5x risk for gestational diabetesWorth knowing · 2.116% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 40% G;T 44% T;T 16%
  • European ancestry (Utah)G;G 50% G;T 40% T;T 10%
  • Han Chinese (Beijing)G;G 59% G;T 38% T;T 3%
  • Japanese (Tokyo)G;G 50% G;T 41% T;T 10%
  • Yoruba (Nigeria)G;G 18% G;T 57% T;T 26%
  • African ancestry (Southwest US)G;G 28% G;T 49% T;T 23%
  • Chinese (Denver)G;G 56% G;T 38% T;T 6%
  • Gujarati IndianG;G 25% G;T 53% T;T 23%
  • Luhya (Kenya)G;G 21% G;T 46% T;T 34%
  • Mexican ancestry (Los Angeles)G;G 59% G;T 36% T;T 5%
  • Maasai (Kenya)G;G 22% G;T 56% T;T 22%
  • TuscanG;G 57% G;T 32% T;T 11%

Conditions, medicines and genes

Other IGF2BP2 SNPs

All IGF2BP2 SNPs

Notes

From SNPedia

Show notes, about 140 words

rs4402960 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.23 (CI: 1.11-1.36, p = 8.1 x 10e-5) associated with type-2 diabetes significantly associated with type-2 diabetes p = 0.00009; in 1,630 Japanese subjects and in 1,064 controls 1,638 type-2 diabetes patients and 1,858 controls *rs4402960 borderline (OR 1.10, 95% CI: 0.99-1.22). Neither rs4402960 or rs1470579 were found to be associated with type-2 diabetes in a study of 3,000 French Caucasians. This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese). Note: rs4402960 is fairly tightly linked (r 2 =0.87) with another IGF2BP2 gene SNP also associated with type-2 diabetes, rs1470579 Called into question by table 1 of

Source and license

Adapted from rs4402960 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.