rs2209972
A SNP in the MARK2P9 gene on chromosome 10. Its most notable genotype is C;C: higher risk for PCOS?
- Gene
- MARK2P9
- Location
- Chr 1092,419,271 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 42%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableNot ratedhigher risk for PCOS?
- C;TNot ratedhigher risk for PCOS?
- T;TNot ratednormal risk
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 35% C;T 34% T;T 31%
- European ancestry (Utah)C;C 49% C;T 38% T;T 13%
- Han Chinese (Beijing)C;C 9% C;T 31% T;T 60%
- Japanese (Tokyo)C;C 9% C;T 43% T;T 48%
- Yoruba (Nigeria)C;C 73% C;T 25% T;T 2%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs2209972, a SNP associated with the insulin-degrading enzyme gene IDE, has been identified as occuring at higher frequency in Chinese female patients with polycystic ovary syndrome (PCOS). The IDE gene has been linked to type-2 diabetes, and many patients with PCOS have endocrine abnormalities that suggest a shared etiology with type-2 diabetes. The risk allele for this SNP is rs2209972(C), and in this study comparing ~300 patients to an equal number of controls the rs2209972(C;C) and rs2209972(C;T) genotypes were associated with higher fasting insulin levels, a higher body mass index (BMI), and (theoretically) insulin resistance (HOMA-IR) than rs2209972(T;T) carriers.
Source and license
Adapted from rs2209972 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.