rs5370(T;T)

Possibly lower HDL cholesterol in women

Magnitude
1.2Minor
Repute
Bad
Frequency
6%Average of 11 populations
On SNPedia
rs5370(T;T)
Gene
EDN1

Frequency

Share of people with T;T in each HapMap population.

  • Gujarati Indian24%
  • Han Chinese (Beijing)9%
  • Chinese (Denver)8%
  • European ancestry (Utah)7%
  • Japanese (Tokyo)5%
  • Mexican ancestry (Los Angeles)3%
  • Maasai (Kenya)3%
  • Tuscan3%
  • Yoruba (Nigeria)3%
  • African ancestry (Southwest US)0%
  • Luhya (Kenya)0%

Other genotypes of rs5370

  1. G;GNot ratedcommonTypical · 0.060% of people
  2. G;TMost notableBadpossibly lower HDL cholesterol in womenMinor · 1.234% of people

All about rs5370

Notes

From SNPedia

One report indicates that women (but not men) with this genotype may have slightly lower levels of HDL cholesterol, but other reports have not observed this. Other observations for this genotype include possibly higher risk for hypertension if you have rheumatoid arthritis, whereas on the other hand, if you are a diabetic, your disease onset may be later and your odds of diabetic retinopathy may be lower.

Source and license

Adapted from rs5370(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.