rs4506565

A SNP in the TCF7L2 gene on chromosome 10. Its most notable genotype is T;T: 1.9x increased risk for type-2 diabetes

Gene
TCF7L2
Location
Chr 10112,996,282 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
27%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.054% of people
  2. A;TBad1.4x increased risk for type-2 diabetesMinor · 1.534% of people
  3. T;TMost notableBad1.9x increased risk for type-2 diabetesWorth knowing · 2.012% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 54% A;T 34% T;T 12%
  • European ancestry (Utah)A;A 53% A;T 35% T;T 12%
  • Han Chinese (Beijing)A;A 95% A;T 5% T;T 0%
  • Japanese (Tokyo)A;A 94% A;T 5% T;T <1%
  • Yoruba (Nigeria)A;A 28% A;T 53% T;T 19%
  • African ancestry (Southwest US)A;A 26% A;T 49% T;T 25%
  • Chinese (Denver)A;A 93% A;T 7% T;T 0%
  • Gujarati IndianA;A 48% A;T 45% T;T 7%
  • Luhya (Kenya)A;A 25% A;T 53% T;T 23%
  • Mexican ancestry (Los Angeles)A;A 53% A;T 36% T;T 10%
  • Maasai (Kenya)A;A 39% A;T 45% T;T 17%
  • TuscanA;A 43% A;T 41% T;T 16%

Conditions, medicines and genes

Other TCF7L2 SNPs

All TCF7L2 SNPs

Notes

From SNPedia

Notes

rs4506565 has been reported in a large study to be associated with type-2 diabetes. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.36 (CI 1.2-1.54), and for homozygotes, 1.88 (CI 1.56-2.27). Note: this is one of two SNPs within the TCF7L2 gene that have been reported to be associated with type-2 diabetes, the other being rs7903146. They have approximately equal power to estimate risk for type-2 diabetes, and the results from one correlate 92% of the time with the other.

T;T

see discussion at rs4506565

Source and license

Adapted from rs4506565 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.