rs3814570

A SNP in the TCF7L2 gene on chromosome 10. Its most notable genotype is C;T: 1.3x increased risk for Crohn's disease with ileal involvement

Gene
TCF7L2
Location
Chr 10112,948,751 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
18%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNormal risk of developing Crohn's diseaseMinor · 1.073% of people
  2. C;TMost notableBad1.3x increased risk for Crohn's disease with ileal involvementMinor · 1.524% of people
  3. T;TBad1.3x increased risk for Crohn's disease with ileal involvementMinor · 1.53% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 73% C;T 24% T;T 3%
  • European ancestry (Utah)C;C 53% C;T 43% T;T 4%
  • Han Chinese (Beijing)C;C 85% C;T 13% T;T 2%
  • Japanese (Tokyo)C;C 91% C;T 9% T;T 0%
  • Yoruba (Nigeria)C;C 81% C;T 19% T;T 0%
  • African ancestry (Southwest US)C;C 86% C;T 12% T;T 2%
  • Chinese (Denver)C;C 85% C;T 15% T;T 0%
  • Gujarati IndianC;C 57% C;T 40% T;T 3%
  • Luhya (Kenya)C;C 86% C;T 15% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 59% C;T 35% T;T 7%
  • Maasai (Kenya)C;C 84% C;T 15% T;T 1%
  • TuscanC;C 40% C;T 46% T;T 14%

Conditions, medicines and genes

Other TCF7L2 SNPs

All TCF7L2 SNPs

Notes

From SNPedia

Notes

rs3814570 is a SNP in the transcription factor 7-like 2 (T-cell specific, HMG-box) TCF7L2 gene. A study of 784 Crohn's disease patients with ileal involvement concluded that rs3814570 was associated with increased risk, but not with risk for colonic Crohn's disease or ulcerative colitis. The odds ratio was 1.27 (CI: 1.07 - 1.52, p = 0.00737). Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.

Source and license

Adapted from rs3814570 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.