rs200185429

A SNP in the SLC30A8 gene on chromosome 8. Its most notable genotype is C;T: Lower type-2 diabetes risk

Gene
SLC30A8
Location
Chr 8117,153,084 (GRCh38)
Highest magnitude
3.0Important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TMost notableGoodLower type-2 diabetes riskImportant · 3.0

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other SLC30A8 SNPs

All SLC30A8 SNPs

Notes

From SNPedia

Notes

rs200185429, also known as c.412C>T, p.Arg138Ter and R138X, is perhaps the best studied of over 10 loss-of-function variants found in the SLC30A8 gene to reduce risk of developing type-2 diabetes by about 2/3rds (OR:0.34, p=1.7×10e−6) in a large Icelandic study published in 2014.

C;T

see discussion and links via main rs-page

Source and license

Adapted from rs200185429 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.