rs8050136
A SNP in the FTO gene on chromosome 16. Its most notable genotype is A;A: 1.4x increased risk for T2D in some populations
- Gene
- FTO
- Location
- Chr 1653,782,363 (GRCh38)
- Highest magnitude
- 1.4Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 34%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBad1.4x increased risk for T2D in some populations
- A;CBad1.2x increased risk for T2D in some populations
- C;CNot ratednormal
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 14% A;C 41% C;C 45%
- European ancestry (Utah)A;A 18% A;C 57% C;C 26%
- Han Chinese (Beijing)A;A 2% A;C 23% C;C 75%
- Japanese (Tokyo)A;A 3% A;C 32% C;C 66%
- Yoruba (Nigeria)A;A 22% A;C 47% C;C 31%
- African ancestry (Southwest US)A;A 25% A;C 44% C;C 32%
- Chinese (Denver)A;A 3% A;C 26% C;C 71%
- Gujarati IndianA;A 7% A;C 37% C;C 56%
- Luhya (Kenya)A;A 20% A;C 53% C;C 27%
- Mexican ancestry (Los Angeles)A;A 2% A;C 38% C;C 60%
- Maasai (Kenya)A;A 26% A;C 51% C;C 23%
- TuscanA;A 24% A;C 43% C;C 33%
Related
Conditions, medicines and genes
Other FTO SNPs
- rs1421085C;C~1.7x increased obesity riskImportant
- rs1121980A;AModerate increase (2.76x) in risk for obesityImportant
- rs9939609A;Aobesity risk and 1.6x risk for T2DImportant
- rs121918214A;GCarrier of a GDFD mutation (see text)Important
- rs16953002A;A1.32x increased risk of melanoma in those with low BMIMinor
- rs1558902A;AHigher BMI than normalTypical
- rs3751812G;GnormalTypical
- rs7195539A;Acommon genotypeTypical
Notes
From SNPedia
Show notes, about 120 words
This SNP is in a linkage block in the FTO gene with rs1121980; see rs1121980 for the association of this block with early onset obesity since it showed the strongest association. This SNP did not show any association with obesity, type-2 diabetes or any other related traits in a study of 3,210 Chinese subjects. Furthermore, the minor allele frequency was much lower in Chinese populations compared to populations of European descent. However, a more recent study of 4,189 Chinese Han subjects combined with a meta-analysis of published studies concluded that rs8050136(A) was associated with both increased risk for type-2 diabetes and obesity. rs8050136 associated with increased food intake, but not of impaired energy expenditure.
Source and license
Adapted from rs8050136 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.