rs3751812
A SNP in the FTO gene on chromosome 16. Its most notable genotype is G;G: normal
- Gene
- FTO
- Location
- Chr 1653,784,548 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 24%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GMost notableNot ratednormal
- G;TNot ratedNo summary available.
- T;TNot ratedincreased risk of obesity
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 66% G;T 28% T;T 5%
- European ancestry (Utah)G;G 27% G;T 56% T;T 18%
- Han Chinese (Beijing)G;G 74% G;T 24% T;T 2%
- Japanese (Tokyo)G;G 66% G;T 32% T;T 3%
- Yoruba (Nigeria)G;G 88% G;T 12% T;T 0%
- African ancestry (Southwest US)G;G 79% G;T 21% T;T 0%
- Chinese (Denver)G;G 72% G;T 26% T;T 3%
- Gujarati IndianG;G 56% G;T 37% T;T 7%
- Luhya (Kenya)G;G 96% G;T 4% T;T 0%
- Mexican ancestry (Los Angeles)G;G 66% G;T 33% T;T 2%
- Maasai (Kenya)G;G 75% G;T 24% T;T <1%
- TuscanG;G 33% G;T 43% T;T 24%
Related
Other FTO SNPs
- rs1421085C;C~1.7x increased obesity riskImportant
- rs1121980A;AModerate increase (2.76x) in risk for obesityImportant
- rs9939609A;Aobesity risk and 1.6x risk for T2DImportant
- rs121918214A;GCarrier of a GDFD mutation (see text)Important
- rs16953002A;A1.32x increased risk of melanoma in those with low BMIMinor
- rs8050136A;A1.4x increased risk for T2D in some populationsMinor
- rs1558902A;AHigher BMI than normalTypical
- rs7195539A;Acommon genotypeTypical
Notes
From SNPedia
Notes
Within the FTO gene, many SNPs appear to be co-inherited. The SNP showing the strongest association with body weight (i.e. body mass index, BMI) is not rs3751812, although this SNP is one of the co-inherited SNPs in the FTO gene region. For more information, refer to the FTO gene or the most studied FTO SNPs, rs9930506 or rs9939609. 23andMe considers rs3751812(T) equivalent to the rs9939609(A) implicated for african americans
Source and license
Adapted from rs3751812 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.