rs1121980

A SNP in the FTO gene on chromosome 16. Its most notable genotype is A;A: Moderate increase (2.76x) in risk for obesity

Gene
FTO
Location
Chr 1653,775,335 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
37%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodaverageTypical · 0.039% of people
  2. A;GBadSlight increase (1.67x) in risk for obesityWorth knowing · 2.545% of people
  3. A;AMost notableBadModerate increase (2.76x) in risk for obesityImportant · 3.016% of people

SNPedia records rs1121980 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 39% A;G 45% A;A 16%
  • European ancestry (Utah)G;G 25% A;G 54% A;A 21%
  • Han Chinese (Beijing)G;G 68% A;G 28% A;A 4%
  • Japanese (Tokyo)G;G 58% A;G 38% A;A 4%
  • Yoruba (Nigeria)G;G 27% A;G 48% A;A 25%
  • African ancestry (Southwest US)G;G 23% A;G 51% A;A 26%
  • Chinese (Denver)G;G 63% A;G 32% A;A 5%
  • Gujarati IndianG;G 41% A;G 51% A;A 9%
  • Luhya (Kenya)G;G 27% A;G 49% A;A 24%
  • Mexican ancestry (Los Angeles)G;G 53% A;G 46% A;A 2%
  • Maasai (Kenya)G;G 14% A;G 59% A;A 27%
  • TuscanG;G 28% A;G 44% A;A 28%

Conditions, medicines and genes

Other FTO SNPs

All FTO SNPs

Notes

From SNPedia

Notes

rs1121980, a SNP in the FTO gene, showed the strongest association of several SNPs in the region with early onset obesity in a study of ~1,000 Caucasians. The odds ratio for the rs1121980(T) risk allele was 1.66 (CI:1.3-2.01); and the odds ratios for heterozygotes and homozygotes (rs1121980(T;T)) were estimated (with a correct p 2 >=0.88 for all). The other 5 SNPs are: * rs9939973 * rs7193144 * rs9940128 * rs8050136 * rs9939609 This SNP is also associated with (severe) obesity in a study of 927 Japanese patients. obesity and type-2 diabetes *rs1121980 *rs7498665 *rs4752856 *rs17782313 *rs2815752 *rs10938397

A;G

see discussion via main rs-page

Source and license

Adapted from rs1121980 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.