rs121918214
A SNP in the FTO gene on chromosome 16. Its most notable genotype is A;G: Carrier of a GDFD mutation (see text)
- Gene
- FTO
- Location
- Chr 1653,873,837 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadCarrier of a GDFD mutation (see text)
- G;GGoodcommon in clinvar
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other FTO SNPs
- rs1421085C;C~1.7x increased obesity riskImportant
- rs1121980A;AModerate increase (2.76x) in risk for obesityImportant
- rs9939609A;Aobesity risk and 1.6x risk for T2DImportant
- rs16953002A;A1.32x increased risk of melanoma in those with low BMIMinor
- rs8050136A;A1.4x increased risk for T2D in some populationsMinor
- rs1558902A;AHigher BMI than normalTypical
- rs3751812G;GnormalTypical
- rs7195539A;Acommon genotypeTypical
Notes
From SNPedia
Notes
aka c.947G>A (p.Arg316Gln or R316Q) GDFD is an acronym for growth retardation, developmental delay, coarse facies, and early death
A;G
Unaffected in absence of a second FTO gene mutation; see text on main rs-page
Source and license
Adapted from rs121918214 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.