rs117767867

A SNP in the SLC16A11 gene on chromosome 17. Its most notable genotype is C;T: 1.25x risk for type 2 diabetes

Gene
SLC16A11
Location
Chr 177,043,011 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe
Minor allele frequency
7%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommonTypical · 0.0
  2. C;TMost notableBad1.25x risk for type 2 diabetesMinor · 1.5
  3. T;TBad1.5x risk for type 2 diabetesMinor · 1.5

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs117767867 is a SNP in the SLC16A11 gene on chromosome 17. This SNP, rs117767867 is considered the tag SNP for a haplotype consisting of 4 missense variants identified as relatively common in the Native American population and having introgressed into modern humans via admixture with Neanderthals. The other 3 missense variants are rs13342692, rs75418188, and rs75493593. This haplotype raises the risk by 25% in heterozygotes and 50% in homozygotes for type-2 diabetes, and it may also lead to the development of type-2 diabetes at a younger age and lower BMI. This haplotype is found at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in Europeans and Africans.

Source and license

Adapted from rs117767867 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.