rs2237897

A SNP in the KCNQ1 gene on chromosome 11. Its most notable genotype is T;T: 1.4x increased risk for diabetic nephropathy in some populations

Gene
KCNQ1
Location
Chr 112,837,316 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratedcommonTypical · 0.091% of people
  2. C;TNot rated1.2x increased risk for diabetic nephropathy in some populationsMinor · 1.29% of people
  3. T;TMost notableNot rated1.4x increased risk for diabetic nephropathy in some populationsMinor · 1.40% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in one HapMap population.

  • European ancestry (Utah)C;C 91% C;T 9% T;T 0%

Conditions, medicines and genes

Other KCNQ1 SNPs

All KCNQ1 SNPs

Notes

From SNPedia

Show notes, about 200 words

nature type-2 diabetes *rs2237897, P = 6.8 times 10-13; OR = 1.41, 95% CI = 1.29–1.55) A study of 754 type-2 diabetes patients plus a meta-analysis concluded that rs2237897(T) was significantly associated with susceptibility to diabetic nephropathy in T2D Japanese subjects (odds ratio = 1.22, CI: 1.10-1.34, corrected p = 0.01). Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore. Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population. Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US. Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes. Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort.

Source and license

Adapted from rs2237897 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.