rs120074177
A SNP in the KCNQ1 gene on chromosome 11. Its most notable genotype is C;G: Romano-Ward Long QT Syndrome
- Gene
- KCNQ1
- Location
- Chr 112,570,682 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other KCNQ1 SNPs
- rs17215500T;TLQT1 form of Long QT syndrome; Jervell and Lange-Nielsen syndromeVery important
- rs179489C;GRomano-Ward Long QT SyndromeVery important
- rs1800171A;GRomano-Ward Long QT SyndromeVery important
- rs12720459C;TLQT1 form of Long QT syndromeVery important
- rs104894252A;GRomano-Ward Long QT SyndromeVery important
- rs104894255A;GRomano-Ward Long QT SyndromeVery important
- rs120074178A;GRomano-Ward Long QT SyndromeVery important
- rs120074179A;GRomano-Ward Long QT SyndromeVery important
Notes
From SNPedia
Notes
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Dominant-negative KvLQT1 mutations underlie the LQT1 form of long QT syndrome. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome. Four novel KVLQT1 and four novel HERG mutations in familial long-QT syndrome. Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test.
Source and license
Adapted from rs120074177 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.