rs114285050

A SNP in the GPR151 gene on chromosome 5. Its most notable genotype is A;G: Slightly lower odds of obesity as well as coronary artery disease

Gene
GPR151
Location
Chr 5146,515,831 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GMost notableGoodSlightly lower odds of obesity as well as coronary artery diseaseWorth knowing · 2.0
  2. G;GGoodcommon/normalTypical · 0.0

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs114285050, also known as Arg95Ter or R95X, represents a variant in the GPR151 gene on chromosome 5. Based on a study of UK BioBank participants, carriers of a rs114285050(A) allele are reported to have 12% lower odds of developing clinical obesity, 14% lower odds of type-2 diabetes (OR 0.86, p=0.006) and 9% lower odds of coronary artery disease (OR 0.91, p=0.01).

A;G

see links and text via main rs-page

Source and license

Adapted from rs114285050 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.