rs1859962

A SNP in the CASC17 gene on chromosome 17. Its most notable genotype is G;G: 1.28x increased risk for prostate cancer

Gene
CASC17
Location
Chr 1771,112,612 (GRCh38)
Highest magnitude
2.3Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
40%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.28x increased risk for prostate cancerWorth knowing · 2.315% of people
  2. G;TGoodnormal riskTypical · 0.047% of people
  3. T;TGoodnormal riskTypical · 0.038% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 15% G;T 47% T;T 38%
  • European ancestry (Utah)G;G 19% G;T 58% T;T 24%
  • Han Chinese (Beijing)G;G 18% G;T 48% T;T 34%
  • Japanese (Tokyo)G;G 2% G;T 43% T;T 55%
  • Yoruba (Nigeria)G;G 2% G;T 38% T;T 60%
  • African ancestry (Southwest US)G;G 9% G;T 37% T;T 54%
  • Chinese (Denver)G;G 15% G;T 55% T;T 30%
  • Gujarati IndianG;G 23% G;T 58% T;T 19%
  • Luhya (Kenya)G;G 5% G;T 42% T;T 54%
  • Mexican ancestry (Los Angeles)G;G 31% G;T 53% T;T 16%
  • Maasai (Kenya)G;G 15% G;T 42% T;T 43%
  • TuscanG;G 28% G;T 43% T;T 28%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 130 words

rs1859962 is a SNP on chromosome 17q24.3, associated with increased risk for prostate cancer in several studies. In a study of over 3,600 Caucasians with prostate cancer, rs1859962 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On its own, the rs1859962(G;G) risk genotype yields an odds ratio for developing prostate cancer of 1.28 (CI: 1.11-1.47, p=5.5x10e-4) and may account for 6.5% of population attributable risk. news linked to Prostate cancer and type-2 diabetes cancer-genetics these snps influence genetic risk for prostate cancer *the haplotype rs6983267 rs1016343 rs4242384 *rs7501939 *rs1859962 *rs2660753 *rs9364554 *rs6465657 *rs10993994 *rs7931342 *rs2735839 *rs5945619 *rs10993994

Source and license

Adapted from rs1859962 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.