rs2272382
A SNP in the TUB gene on chromosome 11. Its most notable genotype is T;T: slightly higher body mass index
- Gene
- TUB
- Location
- Chr 118,089,993 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 37%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableNot ratedslightly higher body mass index
- C;TNot ratedslightly higher body mass index
- C;CGoodcommon/normal
SNPedia records rs2272382 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageT;T 12% C;T 51% C;C 37%
- European ancestry (Utah)T;T 3% C;T 46% C;C 51%
- Han Chinese (Beijing)T;T 7% C;T 71% C;C 22%
- Japanese (Tokyo)T;T 11% C;T 46% C;C 43%
- Yoruba (Nigeria)T;T 26% C;T 42% C;C 32%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 180 words
rs2272382, a SNP in the TUB gene, was found in a study of 492 unrelated type-2 diabetes patients to have a significant effect on body mass index and thus obesity (1.3 kg/m(2), p= 0.016). When two populations were combined, totaling ~1200 patients, the risk allele (rs2272382(A) averaged an increase of 0.35 (–0.14 to 0.83). A follow-up study of 1,680 middle-aged Dutch women found that compared with non-carriers, both rs2272382(A;G) heterozygotes and (A;A) homozygotes derived less energy from fat ((A;G): -0.55+/-0.28%, p=0.05; (A;A): -0.95+/-0.48%, p=0.047). However, both genotypes were associated with an increased energy intake from carbohydrates (0.69+/-0.33%, p= 0.04 and 1.68+/-0.56%, p= 0.003, respectively), mainly because of a higher consumption of mono- and disaccharides. Both this SNP, rs2272382, as well as a linked SNP, rs1528133, were also associated with a higher glycemic load in the diet. The glycemic load was higher among those with rs2272382(A;G) and (A;A) genotypes than among (G;G) homozygotes (+1.49, CI: -0.27-3.24, and +3.89, CI: 0.94-6.85 units, respectively).
Source and license
Adapted from rs2272382 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.