rs2272383

A SNP in the TUB gene on chromosome 11. Its most notable genotype is A;A: normal risk

Gene
TUB
Location
Chr 118,101,952 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormal riskTypical · 0.017% of people
  2. A;GNot ratedhigher body mass indexTypical · 0.036% of people
  3. G;GNot ratedhigher body mass indexTypical · 0.046% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 17% A;G 36% G;G 46%
  • European ancestry (Utah)A;A 42% A;G 48% G;G 11%
  • Han Chinese (Beijing)A;A 16% A;G 55% G;G 30%
  • Japanese (Tokyo)A;A 11% A;G 39% G;G 50%
  • Yoruba (Nigeria)A;A 0% A;G 5% G;G 95%

Conditions, medicines and genes

Other TUB SNPs

All TUB SNPs

Notes

From SNPedia

Notes

rs2272383, a SNP in the TUB gene, was found in a study of 492 unrelated type-2 diabetes patients to have a significant effect on body mass index and thus obesity (1.3 kg/m(2), p= 0.01). When two populations were combined, totaling ~1200 patients, the risk allele rs2272383(G) averaged an increase of 0.21 (–0.28 to 0.70).

Source and license

Adapted from rs2272383 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.